Four of these patients demonstrated epileptiform abnormalities in their electroencephalograms (EEGs).

The episodes ceased after phenytoin or carbamazepine treatment.

In 1977, Pedley and Guilleminault described an unusual type of sleepwalking in six patients all experienced episodes characterized by screaming, vocalization, complex automatisms and ambulation. Keywords: epilepsy, parasomnias, sleep-related hypermotor epilepsy, nocturnal frontal lobe epilepsy, epidemiology For selected drug-resistant SHE patients, epilepsy surgery is the only treatment offering high probability of recovery, both for seizures and for epilepsy-related sleep alterations. Finally, recent studies suggest a poor prognosis in a high percentage of SHE patients with a 20.4% cumulative probability of achieving terminal remission at 10 years from onset. SHE may also exert a negative effect on health-related quality of life, especially in domains pertaining to a patientвЂ™s role in the family, social context and patientвЂ™s illness experience.Дespite a good response to pharmacological treatment, especially with carbamazepine, 30% of SHE patients suffer from drug-resistant seizures. Intellectual disabilities and psychiatric disorders have also been reported in some genetic forms. Moreover, recent studies, adopting a systematic neuropsychological assessment, have shown deficits in memory, executive functions and visuo-spatial abilities in almost half of SHE patients. In fact, seizure frequency can be very high, resulting in nocturnal sleep fragmentation with possible diurnal consequences such as excessive sleepiness and fatigue. Although SHE and autosomal-dominant SHE (ADSHE) have been considered benign epileptic conditions for a long time, emerging data have shed light on the severity of this disorder and some peculiar features can impact negatively on the quality of life of SHE patients. SHE fulfills the definition of rare disease with an estimated minimum prevalence of 1.8/100,000 individuals, and it represents about 10% of drug-resistant surgical cases. Veronica Menghi, 1 Francesca Bisulli, 2 Paolo Tinuper, 2 Lino Nobili 3,4ДЎDepartment of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy 2IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy 3вЂњClaudio MunariвЂќ Center for Epilepsy Surgery, Niguarda Hospital, Milan, Italy 4Department of Neuroscience (DINOGMI), IRCCS, Giannina Gaslini Institute, University of Genoa, Genoa, ItalyДЄbstract: Sleep-related hypermotor epilepsy (SHE), previously called nocturnal frontal lobe epilepsy (NFLE), is a focal epilepsy characterized by asymmetric tonic/dystonic posturing and/or complex hyperkinetic seizures occurring mostly during sleep.

Hyperengine av reviews 2016